Modular Generation of (Iodinated) Polyarenes using Organogermane as Orthogonal Masking Group

While the modular construction of molecules from suitable building blocks is a powerful means to more rapidly generate diversity than through customized syntheses, further evolution underlying coupling methodology key realize widespread applications. We herein disclose complementary approach widely employed Suzuki strategy boron containing precursors, which relies on organogermane as orthogonal functionality and an electrophilic (rather nucleophilic) unmasking event paired with air-stable Pd(I) dimer based bond construction. This allows significantly shorten reaction times for iterative steps and/or close gaps in accessible compound space, enabling straightforward access also iodinated compounds.